Solid Organ Transplant Preservation and Rejection Prevention

About Solid Organ Transplant Preservation and Rejection Prevention

About Solid Organ Transplant Preservation and Rejection Prevention:

Solid organ transplantation is medical procedure removing a diseased organ from a body and re-implanting a viable healthy organ into the body of a recipient restoring proper function of that body system. This is a life-saving or prolonging life therapy for patients with end-stage organ diseases for hundreds of thousands of patients worldwide.

Complications can arise with graft rejection due to mismatched Human leukocyte antigens (HLAs) and are found on the outside surface of cells including Major Histocompatibility Complex ( MHC) receptors. The MHC receptors present a peptide to T lymphocytes where these cells will destroy a pathogen. When there are no destructive pathogens, homeostasis can be achieved. When tissues are transplanted with mismatched HLA, this can elicit a very strong cytotoxic T cell immune response against transplanted tissues
People who have had an organ transplant need antirejection or immunosuppressive medications. They weaken your immune system and decrease your body’s ability to destroy your new organ. But they also decrease how well your body can fight infections, cancer, and other diseases.

Through rapid improvements in immuno-suppressive drugs, opportunistic infection prophylaxis, surgical and anesthetic techniques, and careful pre-operative and post-operative medical surveillance, long-term success rates approaching 80% in five years are achievable in liver, kidney, pancreas, heart, and lung transplant recipients. There are many ways to enhance success in this complex process, including appropriate donor and recipient selection, minimization of peri-operative allograft (donor organ) injury, appropriate use of anti-rejection and anti-infection medications, and close post-operative surveillance for rejection, infection, and recurrent disease.